卢余盛，男，工学博士、博士后，副研究员，硕士研究生导师，福建省高层次人才（C类），福建省智能药物闽台港澳科技合作基地负责人，中国药学会智能药物专业委员会委员，中国生物物理学会氧化还原生物学与医学分会青年委员，福建省药理学会理事，福建省免疫学会免疫与分子诊断专委会委员，Frontiers in Bioengineering and Biotechnology客座主编、Frontiers in Physiology期刊编委、Current Cancer Drug Targets期刊编委、Traditional Medicine Research期刊青年编委，Pharmacological Research、Chemical Engineering Journal、European Journal of Pharmacology、Cell Communication and Signaling、Metabolism、Phytotherapy Research、Journal of Experimental & Clinical Cancer Research等20余个学术期刊审稿人。主要从事肿瘤转移机制及药物、生物材料与纳米药物、生物医学检测等方面的基础及应用研究。近年来，主持国家自然科学基金、中国博士后科学基金、福建省自然科学基金等科研项目多项，授权发明专利2项，获福建省自然科学优秀学术论文二等奖1项，以第一作者或通讯作者发表SCI论文20余篇。指导员工参加老员工创新创业项目国家级1项、省级2项、校级2项，荣获全国老员工生命科学竞赛（科学探究类）国赛三等奖1项、省赛二等奖1项。
邮箱：lu_yu_sheng@126.com
教育经历
2018.03-2018.05 中国医药大学（中国台湾） 访问学者
2016.07-2018.10 福州大学 博士后
2011.09-2016.06 福州大学 生物化工 博士
2006.09-2010.06 黑龙江八一农垦大学 生物技术 本科
主要参与的项目
1.国家自然科学基金青年项目，基于一氧化氮通过改善血液微环境干预肿瘤血路转移的分子机制研究，81703555，主持。
2.中国博士后科学基金面上一等资助，斯诺普利改善血液微环境调控肿瘤血路转移的机制研究，2017M620268，主持。
3.福建省科技创新平台项目，智能药物闽台港澳科技合作基地，2021D043，主持。
4.福建省对外合作项目，远志来源外泌体样纳米囊泡的制备及其抗非小细胞肺癌活性研究，2025I0051，主持。
5.福建省自然科学基金面上项目，循环肿瘤细胞粘附于血管内膜激活TRIM22促进肿瘤转移的分子机制研究，2020J0185，主持。
6.福建省科技创新联合资金项目，中药复方鼻渊通抑制铁死亡改善鼻窦炎的作用及其机制研究，2024Y9493，合作单位项目负责人。
7.福建省科技创新联合资金项目，RhoA蛋白巯亚硝基化修饰在乳腺癌转移中的作用及其机制研究，2023Y9124，合作单位项目负责人。
8.福建省自然科学基金面上项目，基于NF-κB信号通路探讨中药复方“鼻渊通”在慢性鼻窦炎术后治疗中的作用及其分子机制，2022J01850，合作单位项目负责人。
9.福建省自然科学基金引导性项目，基于多功能核酸探针的miRNA检测技术在乳腺癌诊疗中的应用研究，2022Y0016，合作单位项目负责人。
10.福建省海峡博士后交流资助基金，低氧诱导代谢重组调控肿瘤细胞存活和转移的细胞分子机制研究，02510515，主持。
11.福州市科技计划项目，一氧化氮促进蛋白质组巯亚硝基化修饰抑制肿瘤转移的分子机制研究，2021-S-094，主持。
12.福州海洋研究院产学研科技项目，基于鲎重组C因子的高灵敏内毒素检测技术和产品的研发，2021F08，主持。
13.福建省药物新靶点研究重点实验室开放课题：CYR61蛋白巯亚硝基化修饰在肿瘤转移中的作用及其分子机制研究，FJ-YW-2022KF0，主持。
14.发树慈善基金科研项目：核酸探针技术在肿瘤转移早期诊疗中的应用研究，MFK24021，主持。
15.企业横向项目，一种适用于外周血中循环肿瘤细胞扩增培养的技术开发，主持。
16.企业横向项目，薏苡仁油超临界萃取工艺的研发，主持。
主要成果（文章、专利等）
1.Yuying Ye#, Yinyin Yao#, Shanshan He, Xinyi Zhao, Weiyu Wang, Mengting Lin, Yafei Su, Guoqing Wu, Feng Zhou, Li Wang, Chunlian Zhong*, Mingqing Huang*, Hui Wu*, Yusheng Lu*. Biyuantong decoction improves chronic rhinosinusitis by inhibiting inflammatory cell adhesion via NF-кB pathway modulation. Journal of Ethnopharmacology. 2025, 348：119907.
2.Xia Wang, Jingming Zhou, Yu Cheng, Hongmei Wu, Xuejing Su, Rundong Wang, Kaiyan Xiao, Weiwei Zhang, Zhong Chen, Bing Xu, Yusheng Lu*, Hongqiang Qiu*, Lijun Xie*. Hydrazone-based photocages for precise sub-organelle visualization and drug release. Communications Chemistry. 2025, 8: 181.
3.Jingming Zhou#, Yongbo Wei#, Yu Cheng#, Xia Wang, Tong Wu, Weiwei Zhang, Yinyin Yao, Yusheng Lu*, Hongqiang Qiu*, Lijun Xie*. ACQ/AIE transition of rofecoxib-based analogues via combined ring expansion and amino dimethylation strategies and their multiple stimuli-responsive fluorescent behaviors. Journal of Materials Chemistry C. 2025,13: 9494-9501.
4.Weiwei Zhang#, Yongbo Wei#, Fen Lin#, Yinyin Yao, Xia Wang, Yongxiao Sun, Jingming Zhou, Tong Wu, Nannan Chen, Yusheng Lu*, Xiaoping Wu*, Lijun Xie*. Exploration of rational donor–acceptor adjustment strategies to achieve ACQ to AIE transformation and their potential applications as multi-functional AIEgens. Journal of Materials Chemistry C. 2025, 13:9502-9512.
5.Zhong C#, Wang W#, Yao Y#, Lian S, Xie X*, Xu J, He S, Luo L, Ye Z, Zhang J, Huang M, Wang G*, Wang Y*, Lu Y*, Fu C*. TGF-β secreted by cancer cells-platelets interaction activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation. Journal of Cancer. 2025; 16(4):1310-1323.
6.Ye Y#, Lin M#, Zhou G, Wang W, Yao Y, Su Y, Qi J, Zheng Y, Zhong C*, Chen X*, Huang M* and Lu Y*. Fuyuan decoction prevents nasopharyngeal carcinoma metastasis by inhibiting circulating tumor cells/ endothelial cells interplay and enhancing anti-cancer immune response. Frontiers in Pharmacology. 2024, 15:1355650.
7.Wei Liu, Yinyin Yao, Yanbing Ke, Jingming Zhou, Weiwei Zhang, Renfu Li, Yusheng Lu*, Hong Jiang*, and Lijun Xie*. Effects of a Larger N-Heterocyclic Ring in Rofecoxib Analogues on AIE Activity and Multifunctional Applications. European Journal of Organic Chemistry. 2024, e202400175.
8.Chunlian Zhong, Yumei Li, Wulin Li, Shu lian, Ye Li, Changhui Wu, Kun Zhang, Guiyu Zhou, Weiyu Wang, Huo Xu, Mingqing Huang,Vladimir Katanaev, Lee Jia*, Yusheng Lu*. Ganoderma lucidum extract promotes tumor cell pyroptosis and inhibits metastasis in breast cancer. Food and Chemical Toxicology. 2023,174: 113654.
9.Weiyu Wang#, Chengbin Fu#, Mengting Lin#,Yusheng Lu*, Shu Lian, Xiaodong Xie, Guiyu Zhou, Wulin Li, Yiping Zhang, Lee Jia, Chunlian Zhong*, Mingqing Huang*. Fucoxanthin prevents breast cancer metastasis by interrupting circulating tumor cells adhesion and transendothelial migration. Frontiers in Pharmacology. 2022, 13:960375.
10.Chunlian Zhong#, Yusheng Lu#, Yumei Li, Huanzhang Xie, Guiyu Zhou, Lee Jia*. Similarities and differences between embryonic implantation and CTC invasion: Exploring the roles of abortifacients in cancer metastasis chemoprevention. European Journal of Medicinal Chemistry. 2022, 237:114416.
11.Chunlian Zhong, Huan Zhao, Xinwen Xie, Zhi Qi, Yumei Li, Lee Jia*, Jinwei Zhang*, Yusheng Lu*. Protein Kinase C-Mediated Hyperphosphorylation and Lateralization of Connexin 43 Are Involved in Autoimmune Myocarditis-Induced Prolongation of QRS Complex. Frontiers in Physiology. 2022, 13:815301.
12.Yu Zhou, Fan Chen, Xiaodong Xie, Huifang Nie, Shu Lian, Chunlian Zhong, Chengbin Fu, Weiyu Shen, Bifei Li, Yusheng Lu*, Lee Jia*. Tumor-derived Exosome Promotes Metastasis via Altering its Phenotype and Inclusions. Journal of Cancer. 2021, 12: 4240-4246. doi:10.7150/jca.48043.
13.Zhong, CL.#, Yang, JY.#, Lu,YS.#, Xie, HZ.#, Zai, S., Zhang, C., Luo, ZY., Chen, X., Fang, X., Jia*L. Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT. Signal Transduc Targeted Therapy. 2020；5:178.
14.Yusheng Lu, Shu Lian, Yuying Ye, Ting Yu, Haiyan Liang, Yunlong Cheng, Jingjing Xie, Yewei Zhu, Xiaodong Xie, Suhong Yu, Yu Gao, Lee Jia*. S-nitrosocaptopril prevents cancer metastasis by creating the hostile bloodstream environment against circulating tumor cells. Pharmacological Research. 2019. 139: 535-549.
15.Yusheng Lu, Shu Lian, Yunlong Cheng, Yuying Ye, Xiaodong Xie, Chengbin Fu, Chen Zhang, Yewei Zhu, M. Iqbal Parker, Lee Jia*. Circulation patterns and seed-soil compatibility factors cooperate to cause cancer organ-specific metastasis. Experimental Cell Research. 2019. 375: 62-72.
16.Shu Lian, Xiaodong Xie, Yusheng Lu*, Lee Jia*. Checkpoint CD47 Function On Tumor Metastasis And Immune Therapy. OncoTargets and Therapy. 2019. 12:9105-9114.
17.Yunlong Cheng#, Yusheng Lu#, Doudou Zhang, Shu Lian, Haiyan Liang, Yuying Ye, Ruizhi Xie, Shuhui Li, Jiahang Chen, Xuhui Xue, Jingjing Xie, Lee Jia*. Metastatic cancer cells compensate for low energy supplies in hostile microenvironments with bioenergetic adaptation and metabolic reprogramming. International Journal of Oncology. 2018. 53: 2590-2604.
18.Shu Lian#, Yusheng Lu#, Yunlong Cheng, Ting Yu, Xiaodong Xie, Haiyan Liang, Yuying Ye, Lee Jia*. S-nitrosocaptopril interrupts adhesion of cancer cells to vascular endothelium by suppressing cell adhesion molecules via inhibition of the NF-кB and JAK/STAT signal pathways in endothelial cells. European Journal of Pharmacology. 2016; 791:62-71.
19.Yusheng Lu, Haiyan Liang, Ting Yu, Jingjing Xie, Shuming Chen, Haiyan Dong, Patrick J. Sinko, Shu Lian, Jianguo Xu, Jichuang Wang, Suhong Yu, Jingwei Shao, Bo Yuan, Lie Wang, Lee Jia*. Isolation and Characterization of Alive Circulating Tumor Cells in Patients by Immunomagnetic Negative Enrichment Coupled with Flow Cytometry. Cancer. 2015; 121(17):3036-3045.
20.Yusheng Lu, Ting Yu, Haiyan Liang, Jichuang Wang, Jingjing Xie, Jingwei Shao, Yu Gao, Suhong Yu, Shuming Chen, Lie Wang, Lee Jia*. Nitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade. Scientific Reports. 2014, 4: 4344.
